Vasopressin-resistant diabetes insipidus is a rare condition caused by the kidney's inability to respond to ADH due to kidney disease, drug toxicity, or other factors.
It is distinguished by an inability to conserve water while maintaining an optimal free water level. Regardless of the body's hydration level, the kidneys pass large amounts of dilute urine, resulting in symptoms of extreme thirst, copious water intake (up to 20 liters per day), dry skin, and constipation. This results in a large amount of urine being produced.
A variety of factors can cause acquired vasopressin-resistant diabetes insipidus, which is classified into two types: acquired and hereditary, and they are as follows:
Chronic use of certain drugs, such as lithium, demeclocycline (antibiotic), amphotericin B (antifungal agent), Gentamicin, Colchicine, Loop diuretics, and Foscarnet, has been shown to cause NDI in certain patients.
Hypokalemia - Potassium deficiency caused by insufficient dietary intake or loss is usually associated with polyuria, polydipsia, and a renal concentrating defect resistant to ADH.
Develops in people who have a genetic predisposition to kidney disease. An autosomal-recessive form of NDI is caused by a mutation in the gene encoding the ADH-dependent water channel aquaporin-2. Approximately 90% of patients with congenital nephrogenic diabetes insipidus have the X-linked recessive form of the disease.
Extreme thirst,Frequent urination,Headaches,Nausea,Dizziness,Headaches,Blurred vision,Vomiting
Excessive urine production causes nighttime bedwetting,Fluid loss from the body, resulting in constipation,Urine accumulation in the kidney causes swelling of the ureters and large bladder
Drinking enough water, Thiazide diuretics, and Indomethacin